Michael MacCoss, Ph.D.


Professor of Genome Sciences at University of Washington

Michael MacCoss

Dr. Michael MacCoss’s primary area of expertise is in protein biochemistry, nanoflow liquid chromatography, mass spectrometry instrumentation, and computational mass spectrometry data analysis. He has >25 years of mass spectrometry experience that bridges the fields of protein mass spectrometry, isotope ratio mass spectrometry, and quantitative mass spectrometry. His laboratory is also experienced with all aspects of computational analysis of mass spectrometry data – an essential component of any large-scale proteome analysis. Furthermore, Dr. MacCoss’ doctoral training was focused on developing a methodology for measuring human amino acid and protein metabolism in vivo using stable isotope tracers. 

The MacCoss laboratory has been actively applying these tools to essential areas of biology, including but not limited to the basic biology of aging, protein-protein interactions, insulin signaling, measurement of protein half-life, transcriptional regulation, characterization of post-translational modifications, proteogenomics, and clinical diagnostics. His laboratory is widely known for its expertise in developing and supporting proteomics software tools. Dr. MacCoss has been actively involved in the scientific direction and management of NIH centers, program projects, and consortia for 15 years. He was the principal investigator for the NIGMS-funded Yeast Resource Center, a co-investigator of the UW Nathan Shock Center for >15 years, a core director of several P01 grants, had leadership roles in the NCI CPTAC program, and the NIH Common Fund LINCS program.